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Article

In vivo biological response to recombinant interferon-gamma during a phase I dose-response trial in patients with metastatic melanoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jun 1990

Kirkwood J M, Ernstoff M S, Trautman T, Hebert G, Nishida Y, Davis C A, Balzer J, Reich S, Schindler J, Rudnick S A

Abstract excerpt

Interferon-gamma (IFN gamma), as produced by recombinant DNA technology, has shown a wide range of immunomodulatory activity in vitro and in vivo. Clinical studies have attempted to establish a dose-response relationship to define optimal dosage ranges for induction of effector cell function and host response in patients with cancer. We conducted a randomized trial to test the in vivo biologic activity of five...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 2112184
DOI: 10.1200/JCO.1990.8.6.1070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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