In vivo biological response to recombinant interferon-gamma during a phase I dose-response trial in patients with metastatic melanoma.

doi:10.1200/JCO.1990.8.6.1070

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Article

In vivo biological response to recombinant interferon-gamma during a phase I dose-response trial in patients with metastatic melanoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jun 1990

Kirkwood J M, Ernstoff M S, Trautman T, Hebert G, Nishida Y, Davis C A, Balzer J, Reich S, Schindler J, Rudnick S A

Abstract excerpt

Interferon-gamma (IFN gamma), as produced by recombinant DNA technology, has shown a wide range of immunomodulatory activity in vitro and in vivo. Clinical studies have attempted to establish a dose-response relationship to define optimal dosage ranges for induction of effector cell function and...

Topics

2',5'-Oligoadenylate Synthetase
Antigens, Differentiation
Dose-Response Relationship, Drug
Drug Administration Schedule
Enzyme Induction
HLA-DQ Antigens
HLA-DR Antigens
Humans
Infusions, Intravenous
Interferon-gamma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Killer Cells, Natural

Leukocytes, Mononuclear

Melanoma

Phenotype

Randomized Controlled Trials as Topic

Recombinant Proteins

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 2112184
DOI: 10.1200/JCO.1990.8.6.1070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2112184-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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