Article
Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer.
The Journal of experimental medicine - 1 May 1991
Blankenstein T, Qin Z H, Uberla K, Müller W, Rosen H, Volk H D, Diamantstein T
Abstract excerpt
The tumor necrosis factor alpha (TNF-alpha) gene was introduced by retroviral gene transfer into the TNF-alpha-insensitive tumor cell line J558L. Production of 40 pg/ml TNF-alpha by clone J2T12 consistently did not change the growth rate in vitro, but drastically suppressed tumor growth when inje...
Topics
- Alkaline Phosphatase
- Animals
- Antibodies, Monoclonal
- Cell Movement
- Female
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Immunohistochemistry
- Interleukin-6
- Macrophage-1 Antigen
- Macrophages
- Mice
- Mice, Inbred BALB C
- Multiple Myeloma
- Phenotype
- Plasmacytoma
- Retroviridae
- Transfection