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Article

Association of the TNF-alpha -308 G/A promoter polymorphism with insulin resistance in obesity.

Obesity research - 1 May 2002

Dalziel Bronwen, Gosby Alison K, Richman Rosemary M, Bryson Janet M, Caterson Ian D

Abstract excerpt

OBJECTIVE: Obesity is a major risk factor for the development of type 2 diabetes. Tumor necrosis factor (TNF)-alpha is a candidate gene for the development of both obesity and insulin resistance. We investigated whether a common polymorphism in the promoter region (-308 G/A) of the TNF-alpha gene was associated with increased risk for the development of insulin resistance and cardiovascular disease in an obese...

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Identifiers

PMID: 12006640
DOI: 10.1038/oby.2002.55

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of the TNF-alpha -308 G/A promoter polymorphism with insulin resistance in obesity.PMID 12006640Read ↗

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TNF-αG-308A polymorphism is associated with insulin resistance: a meta-analysis.Semantic proximity Read ↗

Meta-analysis on the G-308A tumor necrosis factor alpha gene variant and phenotypes associated with the metabolic syndrome.Semantic proximity Read ↗

Association of TNF-α promoter gene G-308A polymorphism with metabolic syndrome, insulin resistance, serum TNF-α and leptin levels in Indian adult women.Semantic proximity Read ↗

Excessive fat accumulation is associated with the TNF alpha-308 G/A promoter polymorphism in women but not in men.Semantic proximity Read ↗

Risk of obesity and type 2 diabetes with tumor necrosis factor-α 308G/A gene polymorphism in metabolic syndrome and coronary artery disease subjects.Semantic proximity Read ↗

The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with hypertension in adolescents harboring the metabolic syndrome.Semantic proximity Read ↗

Association between anthropometric measures of obesity, metabolic disturbances and polymorphism G-308A of the tumor necrosis factor-alpha gene in children.Semantic proximity Read ↗

The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity.Semantic proximity Read ↗

Association between -308G/A TNFA Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Systematic Review.Semantic proximity Read ↗

The G-308A variant of the Tumor Necrosis Factor-α (TNF-α) gene is not associated with obesity, insulin resistance and body fat distributionSemantic proximity Read ↗

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