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Article

Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance.

Endocrinology - 1 Apr 2002

Xu Haiyan, Hirosumi Jiro, Uysal K Teoman, Guler A Deniz, Hotamisligil Gökhan S

Abstract excerpt

Aberrant TNF alpha expression in adipocytes is a molecular mechanism by which insulin action is modulated in adipose tissue. While this might be a compensatory response to limit adipose expansion, neither the mechanisms underlying this local effect nor its systemic biological consequences have be...

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Source

Identifiers

PMID: 11897709
DOI: 10.1210/endo.143.4.8715

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11897709-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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