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Article

Autosomal dominant spastic paraplegia linked to chromosome 2p: clinical and genetic studies of a large Japanese pedigree.

Journal of the neurological sciences - 3 Oct 1997

Matsuura T, Sasaki H, Wakisaka A, Hamada T, Moriwaka F, Tashiro K

Abstract excerpt

Autosomal dominant spastic paraplegia (ADSP) is a genetically heterogenous disorder. To date, 3 loci of ADSP have been identified on chromosome 2p, 14q, and 15q, but specific gene mutations remain unknown. To determine the genetic background of ADSP in the Japanese, we studied a large 3-generation pedigree, clinically and genetically. Of the 36 individuals clinically examined, 15 were affected. The main feature...

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PMID: 9335012
DOI: 10.1016/s0022-510x(97)00107-x

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