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Article

A new locus for autosomal dominant "pure" hereditary spastic paraplegia mapping to chromosome 12q13, and evidence for further genetic heterogeneity.

American journal of human genetics - 1 Sept 1999

Reid E, Dearlove A M, Rhodes M, Rubinsztein D C

Abstract excerpt

Autosomal dominant pure hereditary spastic paraplegia (ADPHSP) is clinically characterized by slowly progressive lower-limb spasticity. The condition is genetically heterogeneous, and loci have been mapped at chromosomes 2p, 8q, 14q, and 15q. We have performed a genomewide linkage screen on a large family with ADPHSP, in which linkage to all four previously known loci was excluded. Analysis of markers on...

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Identifiers

PMID: 10441583
DOI: 10.1086/302555
PMCID: PMC1377983

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Source receipt: pubmed, retrieved 7 Sept 2026.

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