Article
Autosomal dominant, familial spastic paraplegia, type I: clinical and genetic analysis of a large North American family.
Neurology - 1 Feb 1995
Fink J K, Sharp G B, Lange B M, Wu C B, Haley T, Otterud B, Peacock M, Leppert M
Abstract excerpt
"Familial spastic paraplegia" (FSP) refers to clinically and genetically diverse syndromes characterized by insidiously progressive lower extremity spasticity. We evaluated 126 members of a large kindred, including 31 affected subjects, in which FSP was transmitted as a stereotyped, autosomal dominant disorder that showed complete genetic penetrance. Affected subjects developed insidiously progressive gait...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.