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Article

Autosomal dominant spastic paraplegia: refined SPG8 locus and additional genetic heterogeneity.

Neurology - 10 Nov 1999

Reid E, Dearlove A M, Whiteford M L, Rhodes M, Rubinsztein D C

Abstract excerpt

OBJECTIVE: To map the gene responsible for autosomal dominant pure hereditary spastic paraplegia (ADPHSP) in a large affected family. BACKGROUND: Autosomal dominant pure hereditary spastic paraplegia (ADPHSP) is genetically heterogeneous, and loci have been mapped at chromosomes 2p (SPG4), 14q (SPG3), 15q (SPG6), and recently, in a single family, at chromosome 8q24 (SPG8). METHODS: The authors carried out a...

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Identifiers

PMID: 10563637
DOI: 10.1212/wnl.53.8.1844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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