The phenotype of "pure" autosomal dominant spastic paraplegia.

doi:10.1212/wnl.44.7.1274

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Article

The phenotype of "pure" autosomal dominant spastic paraplegia.

Neurology - 1 Jul 1994

Dürr A, Brice A, Serdaru M, Rancurel G, Derouesné C, Lyon-Caen O, Agid Y, Fontaine B

Abstract excerpt

We studied 23 families with "pure" autosomal dominant spastic paraplegia. Examination of 142 at-risk individuals allowed identification of 70 patients, including 12 who were clinically affected but unaware of symptoms. The frequency of lower limb muscle weakness, decreased vibration sense, hyperr...

Topics

Adult
Age of Onset
Aged
Aged, 80 and over
Female
Genes, Dominant
Humans
Male
Middle Aged
Nervous System
Paraplegia
Pedigree
Phenotype
Time Factors

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