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Article

A new locus for autosomal dominant pure spastic paraplegia, on chromosome 2q24-q34.

American journal of human genetics - 1 Feb 2000

Fontaine B, Davoine C S, Dürr A, Paternotte C, Feki I, Weissenbach J, Hazan J, Brice A

Abstract excerpt

Hereditary spastic paraplegia (HSP) comprises a group of clinically and genetically heterogeneous disorders causing progressive spasticity and weakness of the lower limbs. We report a large family of French descent with autosomal dominant pure HSP. We excluded genetic linkage to the known loci causing HSP and performed a genomewide search. We found evidence for linkage of the disorder to polymorphic markers on...

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Identifiers

PMID: 10677329
DOI: 10.1086/302776
PMCID: PMC1288122

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