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Article

Autosomal dominant pure spastic paraplegia: a clinical, paraclinical, and genetic study.

Journal of neurology, neurosurgery, and psychiatry - 1 Jan 1998

Nielsen J E, Krabbe K, Jennum P, Koefoed P, Jensen L N, Fenger K, Eiberg H, Hasholt L, Werdelin L, Sørensen S A

Abstract excerpt

OBJECTIVES: At least three clinically indistinguishable but genetically different types of autosomal dominant pure spastic paraplegia (ADPSP) have been described. In this study the clinical, genetic, neurophysiological, and MRI characteristics of ADPSP were investigated. METHODS: Sixty three at risk members from five families were clinically evaluated. A diagnostic index was constructed for the study....

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Identifiers

PMID: 9436729
DOI: 10.1136/jnnp.64.1.61
PMCID: PMC2169895

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