Escherichia coli DNA topoisomerase I and suppression of killing by Tn5 transposase overproduction: topoisomerase I modulates Tn5 transposition.

doi:10.1128/JB.180.22.5866-5874.1998

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Article

Escherichia coli DNA topoisomerase I and suppression of killing by Tn5 transposase overproduction: topoisomerase I modulates Tn5 transposition.

Journal of bacteriology - 1 Nov 1998

Yigit H, Reznikoff W S

Abstract excerpt

Tn5 transposase (Tnp) overproduction is lethal to Escherichia coli. The overproduction causes cell filamentation and abnormal chromosome segregation. Here we present three lines of evidence strongly suggesting that Tnp overproduction killing is due to titration of topoisomerase I. First, a suppre...

Topics

Chromosome Mapping
DNA Topoisomerases, Type I
DNA Topoisomerases, Type II
DNA, Bacterial
Escherichia coli
Gene Expression Regulation, Bacterial
Phenotype
RNA, Messenger
Transposases

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