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Article

Bacterial cell killing mediated by topoisomerase I DNA cleavage activity.

The Journal of biological chemistry - 18 Nov 2005

Cheng Bokun, Shukla Shikha, Vasunilashorn Sarinnapha, Mukhopadhyay Somshuvra, Tse-Dinh Yuk-Ching

Abstract excerpt

DNA topoisomerases are important clinical targets for antibacterial and anticancer therapy. At least one type IA DNA topoisomerase can be found in every bacterium, making it a logical target for antibacterial agents that can convert the enzyme into poison by trapping its covalent complex with DNA. However, it has not been possible previously to observe the consequence of having such a stabilized covalent complex...

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Identifiers

PMID: 16159875
DOI: 10.1074/jbc.M509722200
PMCID: PMC1351368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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