Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a major locus for islet inflammation and fibrosis in the spontaneously diabetic Torii rat.

Physiological genomics - 17 Sept 2008

Fuse Masanori, Yokoi Norihide, Shinohara Masami, Masuyama Taku, Kitazawa Riko, Kitazawa Sohei, Seino Susumu

Abstract excerpt

The pathogenesis of inflammation and fibrosis in the pancreatic islets in diabetes is largely unknown. Spontaneously diabetic Torii (SDT) rats exhibit inflammation and fibrosis in and around the islets during the development of the disease. We investigated genetic factors for diabetes, islet inflammation, and fibrosis in the SDT rat. We produced F1 and F2 rats by intercross between SDT and F344 rats, examined the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Mammalian
Share to Diabetes Mellitus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibrosis

Share to Islets of Langerhans

Share to Pancreatitis

Share to Quantitative Trait Loci

Share to Rats, Inbred F344

Share to Rats, Inbred Strains

Source

Identifiers

PMID: 18612083
DOI: 10.1152/physiolgenomics.90214.2008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a major locus for islet inflammation and fibrosis in the spontaneously diabetic Torii rat.PMID 18612083Read ↗

Genetic analysis for diabetes in a new rat model of nonobese type 2 diabetes, Spontaneously Diabetic Torii rat.Semantic proximity Read ↗

A non-MHC locus essential for autoimmune type I diabetes in the Komeda Diabetes-Prone rat.Semantic proximity Read ↗

Genetic analysis of obese diabetes in the TSOD mouse.Semantic proximity Read ↗

Genetic dissection of Iddm26 in the spontaneously diabetic BBDP rat.Semantic proximity Read ↗

A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes.Semantic proximity Read ↗

Type 1 Diabetes in the BB Rat: A Polygenic DiseaseSemantic proximity Read ↗

Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci.Semantic proximity Read ↗

Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.Semantic proximity Read ↗

NOD alleles at Idd1 and Idd2 loci drive exocrine pancreatic inflammation.Semantic proximity Read ↗

Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency.Semantic proximity Read ↗

Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3.Semantic proximity Read ↗

High-resolution quantitative trait locus analysis reveals multiple diabetes susceptibility loci mapped to intervals<800 kb in the species-conserved Niddm1i of the GK rat.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.