Article
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus.
Nature genetics - 1 Aug 2002
Yokoi Norihide, Komeda Kajuro, Wang He-Yao, Yano Hideki, Kitada Kazuhiro, Saitoh Yuka, Seino Yutaka, Yasuda Kazuki, Serikawa Tadao, Seino Susumu
Abstract excerpt
The autoimmune disease type 1 diabetes mellitus (insulin-dependent diabetes mellitus, IDDM) has a multifactorial etiology. So far, the major histocompatibility complex (MHC) is the only major susceptibility locus that has been identified for this disease and its animal models. The Komeda diabetes-prone (KDP) rat is a spontaneous animal model of human type 1 diabetes in which the major susceptibility locus...
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