Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishment of two substrains, diabetes-prone and non-diabetic, from Long-Evans Tokushima Lean (LETL) rats.

Endocrine journal - 1 Dec 1998

Komeda K, Noda M, Terao K, Kuzuya N, Kanazawa M, Kanazawa Y

Abstract excerpt

Diabetes mellitus in Long-Evans Tokushima Lean (LETL) rats closely resembles type 1 diabetes in human beings, e.g., no gender differences in the incidence of diabetes and no T lymphopenia. Although the LETL rats have been established as an inbred strain, the incidence of diabetes is only approximately 20%. In the present study, we established two substrains, one a diabetes-prone (KDP) and the other a non-diabetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Blood Glucose
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin

Share to Pancreas

Share to Polymorphism, Restriction Fragment Length

Share to Rats, Inbred Strains

Share to Rats, Long-Evans

Source

Identifiers

PMID: 10395228
DOI: 10.1507/endocrj.45.737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishment of two substrains, diabetes-prone and non-diabetic, from Long-Evans Tokushima Lean (LETL) rats.PMID 10395228Read ↗

A non-MHC locus essential for autoimmune type I diabetes in the Komeda Diabetes-Prone rat.Semantic proximity Read ↗

A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes.Semantic proximity Read ↗

Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.Semantic proximity Read ↗

Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.Semantic proximity Read ↗

Crosses between diabetic BB/OK and wild rats confirm that a third gene is essential for diabetes development.Semantic proximity Read ↗

Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus.Semantic proximity Read ↗

Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.Semantic proximity Read ↗

Environmental stress modifies glycemic control and diabetes onset in type 2 diabetes prone Otsuka Long Evans Tokushima Fatty (OLETF) rats.Semantic proximity Read ↗

Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat.Semantic proximity Read ↗

Genetic analysis for diabetes in a new rat model of nonobese type 2 diabetes, Spontaneously Diabetic Torii rat.Semantic proximity Read ↗

Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes.Semantic proximity Read ↗

LEW.1WR1 Rats Develop Autoimmune Diabetes Spontaneously and in Response to Environmental PerturbationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.