Article
Very short patch repair: reducing the cost of cytosine methylation.
Molecular microbiology - 1 May 1996
Lieb M, Bhagwat A S
Abstract excerpt
In Escherichia coli and related bacteria, the product of gene dcm methylates the second cytosine of 5'-CCWGG sequences (where W is A or T). Deamination of 5-methylcytosine (5meC) results in C to T mutations. The mutagenic potential of 5meC is reduced by a system called very short patch (VSP) repair, which replaces T with C. T:G and U:G mispairs in the methylatable sequence and in related sequences are recognized...
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