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Article

Catechol-O-methyltransferase gene and obsessive-compulsive symptoms in patients with recent-onset schizophrenia: preliminary results.

Psychiatry research - 15 Jan 2008

Zinkstok Janneke, van Nimwegen Lonneke, van Amelsvoort Therese, de Haan Lieuwe, Yusuf Maryan Abdulkadir, Baas Frank, Linszen Don

Abstract excerpt

The catechol-O-methyltransferase (COMT) gene is a candidate gene for schizophrenia because of its role in the breakdown of dopamine in the prefrontal cortex. The COMT gene contains a functional polymorphism changing enzyme activity that has been associated with some neuropsychiatric (endo)phenotypes, e.g. cognitive performance and anxiety. In this study we investigated the association between the COMT Val(158)Met...

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Source

Identifiers

PMID: 17850881
DOI: 10.1016/j.psychres.2007.02.001

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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