Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy.

doi:10.1111/j.1440-1819.1997.tb02593.x

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Article

Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy.

Psychiatry and clinical neurosciences - 1 Aug 1997

Morinobu S, Tanaka T, Kawakatsu S, Totsuka S, Koyama E, Chiba K, Ishizaki T, Kubota T

Abstract excerpt

The relationship between the genetic polymorphism of S-mephenytoin 4'-hydroxylation catalyzed by CYP2C19 and the N-demethylation of imipramine was examined in 10 Japanese depressed patients. Five patients, who were poor metabolizers of S-mephenytoin, were determined to be either homozygous for a...

Topics

Adult
Antidepressive Agents, Tricyclic
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme System
DNA Mutational Analysis
Depressive Disorder, Major
Dose-Response Relationship, Drug
Exons
Female
Genetic Carrier Screening
Genotype
Humans
Imipramine

Source

Open in PubMed

Identifiers

PMID: 9316174
DOI: 10.1111/j.1440-1819.1997.tb02593.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9316174-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Male

Middle Aged

Mixed Function Oxygenases

Polymorphism, Genetic