Article
Association of graded allele-specific changes in CYP2D6 function with imipramine dose requirement in a large group of depressed patients.
Molecular psychiatry - 1 Jun 2008
Schenk P W, van Fessem M A C, Verploegh-Van Rij S, Mathot R A A, van Gelder T, Vulto A G, van Vliet M, Lindemans J, Bruijn J A, van Schaik R H N
Abstract excerpt
The inactivation and clearance of the tricyclic antidepressant imipramine is dependent on CYP2D6 activity. First, CYP2C19 converts imipramine into the active metabolite desipramine, which is then inactivated by CYP2D6. This retrospective single center study aimed to prove whether CYP2C19 and ample CYP2D6 genotyping (taking into consideration four null alleles and three decreased-activity alleles) could be used to...
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