Article
Effects of Cytochrome P450 (CYP) 2C19 Genotypes on Steady-State Plasma Concentrations of Escitalopram and its Desmethyl Metabolite in Japanese Patients With Depression.
Therapeutic drug monitoring - 1 Jun 2018
Tsuchimine Shoko, Ochi Shinichiro, Tajiri Misuzu, Suzuki Yutaro, Sugawara Norio, Inoue Yoshimasa, Yasui-Furukori Norio
Abstract excerpt
BACKGROUND: Plasma concentrations of the S-enantiomer of citalopram were different between extensive and poor CYP2C19 metabolizers in healthy subjects and depressed patients. However, most studies applied dose-corrected concentrations. Thus, we studied the effects of polymorphisms of the CYP2C19 gene on raw plasma drug concentrations in Japanese patients with depression. METHODS: Subjects in this study consisted...
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