Article
Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms--a population study.
British journal of clinical pharmacology - 1 Apr 1995
Madsen H, Nielsen K K, Brøsen K
Abstract excerpt
1. Sparteine and mephenytoin phenotyping tests were carried out in 327 healthy Danish subjects. Two weeks later each subject took 25 mg imipramine followed by urine collection for 24 h. The urinary content of imipramine, desipramine, 2-hydroxy-imipramine and 2-hydroxy-desipramine was assayed by h...
Topics
- Adult
- Chromatography, High Pressure Liquid
- Cohort Studies
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Denmark
- Desipramine
- Female
- Genotype
- Heterozygote
- Homozygote
- Humans
- Hydroxylation
- Imipramine
- Male
- Mephenytoin
- Middle Aged