Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy

21 Feb 2018

Abstract excerpt

Macroautophagy/autophagy is a conserved catabolic process that promotes survival during stress. Autophagic dysfunction is associated with pathologies such as cancer and neurodegenerative diseases. Thus, autophagy must be strictly modulated at multiple levels (transcriptional, post-transcriptional, translational and post-translational) to prevent deregulation. Relatively little is known about the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to CRISPR and Genetic Engineering
Share to Plant Virus Research Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29465287
DOI: 10.1080/15548627.2018.1441648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagyPMID 29465287Read ↗

Proper 5'-3' cotranslational mRNA decay in yeast requires import of Xrn1 to the nucleus.Semantic proximity Read ↗

The roles of the exoribonucleases DIS3L2 and XRN1 in human diseaseSemantic proximity Read ↗

XRN 5'→3' exoribonucleases: structure, mechanisms and functions.Semantic proximity Read ↗

Autophagy of the Nucleus in Health and DiseaseSemantic proximity Read ↗

Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer ImmunotherapySemantic proximity Read ↗

Nonsense-Mediated Decay Restricts LncRNA Levels in Yeast Unless Blocked by Double-Stranded RNA Structure.Semantic proximity Read ↗

SKI complex: A multifaceted cytoplasmic RNA exosome cofactor in mRNA metabolism with links to disease, developmental processes, and antiviral responsesSemantic proximity Read ↗

High-throughput siRNA screening reveals functional interactions and redundancies of human processive exoribonucleasesSemantic proximity Read ↗

Mutational analysis of exoribonuclease I from Saccharomyces cerevisiae.Semantic proximity Read ↗

Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasisSemantic proximity Read ↗

EXOSC10-mediated pre-tRNA surveillance safeguards neuron survivalSemantic proximity Read ↗

The EDC4-XRN1 axis controls P-body dynamics to link mRNA decapping with decaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.