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Article

Structural and biochemical studies of the 5'→3' exoribonuclease Xrn1.

Nature structural & molecular biology - 1 Mar 2011

Chang Jeong Ho, Xiang Song, Xiang Kehui, Manley James L, Tong Liang

Abstract excerpt

The 5'→3' exoribonucleases (XRNs) have important functions in transcription, RNA metabolism and RNA interference. The structure of Rat1 (also known as Xrn2) showed that the two highly conserved regions of XRNs form a single, large domain that defines the active site of the enzyme. Xrn1 has a 510-residue segment after the conserved regions that is required for activity but is absent from Rat1/Xrn2. Here we report...

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Identifiers

PMID: 21297639
DOI: 10.1038/nsmb.1984
PMCID: PMC3075561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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