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Article

Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1.

Nature - 9 Apr 2009

Xiang Song, Cooper-Morgan Amalene, Jiao Xinfu, Kiledjian Megerditch, Manley James L, Tong Liang

Abstract excerpt

The 5'-->3' exoribonucleases (XRNs) comprise a large family of conserved enzymes in eukaryotes with crucial functions in RNA metabolism and RNA interference. XRN2, or Rat1 in yeast, functions primarily in the nucleus and also has an important role in transcription termination by RNA polymerase II (refs 7-14). Rat1 exoribonuclease activity is stimulated by the protein Rai1 (refs 15, 16). Here we report the crystal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19194460
DOI: 10.1038/nature07731
PMCID: PMC2739979

Genes

XRN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1.PMID 19194460Read ↗

XRN 5'→3' exoribonucleases: structure, mechanisms and functions.Semantic proximity Read ↗

A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe.Semantic proximity Read ↗

Unraveling the mechanistic features of RNA polymerase II termination by the 5'-3' exoribonuclease Rat1.Semantic proximity Read ↗

Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activity.Semantic proximity Read ↗

The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II.Semantic proximity Read ↗

Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes.Semantic proximity Read ↗

Rat1p and Xrn1p are functionally interchangeable exoribonucleases that are restricted to and required in the nucleus and cytoplasm, respectively.Semantic proximity Read ↗

Structural and biochemical studies of the 5'→3' exoribonuclease Xrn1.Semantic proximity Read ↗

Comprehensive classification of the PIN domain-like superfamilySemantic proximity Read ↗

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts.Semantic proximity Read ↗

Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complexSemantic proximity Read ↗

Identification of a novel deFADding activity in 5’ to 3’ exoribonucleasesSemantic proximity Read ↗

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