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Article

Mice lacking a functional chk gene have no apparent defects in the hematopoietic system.

Biochemistry and molecular biology international - 1 Sept 1997

Samokhvalov I, Hendrikx J, Visser J, Belyavsky A, Sotiropolous D, Gu H

Abstract excerpt

Non-receptor tyrosine kinase Chk has been implicated in hematopoietic development. To study the function of Chk in vivo, we have generated chk-deficient mice using gene targeting. Overall development of mice homozygous for this mutation was apparently normal. Blood counts, FACS analysis of hematopoietic cell populations, CFU-C and CAFC assays showed no significant difference between wild type and mutant animals....

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Identifiers

PMID: 9315289
DOI: 10.1080/15216549700203881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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