Article
Mutant mice lacking Crk-II caused by the gene trap insertional mutagenesis: Crk-II is not essential for embryonic development.
Biochemical and biophysical research communications - 20 Dec 1999
Imaizumi T, Araki K, Miura K, Araki M, Suzuki M, Terasaki H, Yamamura K
Abstract excerpt
Crk family adapter proteins including Crk-II, Crk-I, and Crk-L consist mostly of SH2 and SH3 domains. Through the interactions between SH2 domain and phosphotyrosine residues and/or between SH3 domain and proline-rich motifs, they are involved in a variety of signaling cascades. Despite their essential roles in the signal transductions, knock-out mice of these molecules have not been reported yet. We performed...
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