Article
Colon Tumors with the Simultaneous Induction of Driver Mutations in APC, KRAS, and PIK3CA Still Progress through the Adenoma-to-carcinoma Sequence.
Cancer prevention research (Philadelphia, Pa.) - 1 Oct 2015
Hadac Jamie N, Leystra Alyssa A, Paul Olson Terrah J, Maher Molly E, Payne Susan N, Yueh Alexander E, Schwartz Alexander R, Albrecht Dawn M, Clipson Linda, Pasch Cheri A, Matkowskyj Kristina A, Halberg Richard B, Deming Dustin A
Abstract excerpt
Human colorectal cancers often possess multiple mutations, including three to six driver mutations per tumor. The timing of when these mutations occur during tumor development and progression continues to be debated. More advanced lesions carry a greater number of driver mutations, indicating tha...
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