Article
Mutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimeras.
Journal of virology - 1 Oct 1997
Everly D N, Read G S
Abstract excerpt
During lytic herpes simplex virus (HSV) infections, the half-lives of host and viral mRNAs are regulated by the HSV virion host shutoff (Vhs) protein (UL41). The sequences of the UL41 polypeptides of HSV type 1 (HSV-1) strain KOS and HSV-2 strain 333 are 87% identical. In spite of this similarity...
Topics
- Alleles
- Alphaherpesvirinae
- Amino Acid Sequence
- Animals
- Base Sequence
- Chlorocebus aethiops
- Conserved Sequence
- DNA Mutational Analysis
- Genes, Reporter
- Genes, Viral
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Recombinant Fusion Proteins
- Restriction Mapping
- Sequence Alignment
- Sequence Homology, Amino Acid
- Simplexvirus
- Species Specificity