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Article

Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesis

1 Nov 1995

Abstract excerpt

The herpes simplex virus type 1 (HSV-1) UL41 gene product, virion host shutoff (vhs), has homologs among five alphaherpesviruses (HSV-1, HSV-2, pseudorabies virus, varicella-zoster virus, and equine herpesvirus 1), suggesting a role for this protein in neurotropism. A mutant virus, termed UL41NHB, which carries a nonsense linker in the UL41 open reading frame at amino acid position 238 was generated. UL41NHB and...

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Identifiers

PMID: 7474089
DOI: 10.1128/jvi.69.11.6779-6786.1995

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