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Article

Herpes simplex virus 2 virion host shutoff protein interferes with type I interferon production and responsiveness.

Virology - 25 Apr 2004

Duerst Rebecca J, Morrison Lynda A

Abstract excerpt

The herpes simplex virus 2 (HSV-2) virion host shutoff (vhs) protein is a ribonuclease contained in the virion tegument. vhs-deficient mutants of HSV-2 are profoundly attenuated in vivo, and we have previously shown that replication and virulence of vhs-deficient HSV-2 are largely restored to levels of wild-type virus in mice lacking the interferon alpha/beta receptor (IFNalphabetaR(-/-)). This result...

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Identifiers

PMID: 15063125
DOI: 10.1016/j.virol.2004.01.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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