Mutational analysis of the herpes simplex virus virion host shutoff protein: evidence that vhs functions in the absence of other viral proteins.

Abstract excerpt

Herpes simplex virus (HSV) virions contain one or more factors that trigger rapid shutoff of host protein synthesis and accelerated decay of cellular and viral mRNAs in infected cells. HSV isolates bearing mutations at the virion host shutoff (vhs) locus (gene UL41) are defective for both processes, indicating that the vhs protein is required; however, it is not clear whether the role of vhs in shutoff is direct...

Topics

• Amino Acid Sequence
• Animals
• Base Sequence
• Chlorocebus aethiops
• DNA Mutational Analysis
• Gene Expression Regulation, Viral
• Molecular Sequence Data
• Mutagenesis, Insertional
• Oligodeoxyribonucleotides
• Phenotype