Article
Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide.
Journal of virology - 1 Dec 1993
Read G S, Karr B M, Knight K
Abstract excerpt
The virion host shutoff (vhs) gene (UL41) of herpes simplex virus type 1 (HSV-1) encodes a virion component that induces degradation of host mRNAs and the shutoff of most host protein synthesis. Subsequently, the vhs protein accelerates the turnover of all kinetic classes of viral mRNA. To identi...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Blotting, Western
- Gene Deletion
- Genetic Markers
- Genetic Variation
- Herpesvirus 1, Human
- Lac Operon
- Molecular Sequence Data
- Mutation
- Phenotype
- Phosphorylation
- Plasmids
- Precipitin Tests
- Protein Processing, Post-Translational
- Recombinant Fusion Proteins