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Article

Pathogenesis of herpes simplex virus type 2 virion host shutoff (vhs) mutants.

Journal of virology - 1 Mar 2002

Smith Tracy J, Morrison Lynda A, Leib David A

Abstract excerpt

During lytic infection, the virion host shutoff (vhs) protein mediates the rapid degradation of mRNA and the shutoff of host protein synthesis. In vivo, herpes simplex virus type 1 (HSV-1) mutants lacking vhs activity are profoundly attenuated. Homologs of vhs exist in all of the neurotropic herpesviruses, and the goal of this study was to determine the virulence of HSV-2 mutants lacking vhs. Two HSV-2...

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Identifiers

PMID: 11836383
DOI: 10.1128/jvi.76.5.2054-2061.2002
PMCID: PMC153813

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Source receipt: pubmed, retrieved 7 Sept 2026.

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