The virion host shutoff protein of herpes simplex virus inhibits reporter gene expression in the absence of other viral gene products.

doi:10.1006/viro.1995.1431

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Article

The virion host shutoff protein of herpes simplex virus inhibits reporter gene expression in the absence of other viral gene products.

Virology - 20 Aug 1995

Pak A S, Everly D N, Knight K, Read G S

Abstract excerpt

The virion host shutoff (vhs) function of herpes simplex virus induces degradation of host mRNAs at early times and rapid turnover of viral mRNAs throughout infection. Previous studies have shown that disruption of the UL41 gene abrogates vhs activity, but have not determined whether the UL41 pol...

Topics

Alleles
Animals
Base Sequence
Chlorocebus aethiops
DNA, Viral
Gene Expression Regulation, Viral
Genes, Reporter
Molecular Sequence Data
Mutation
Ribonucleases
Simplexvirus
Transfection
Vero Cells
Viral Proteins

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