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The virion host shutoff protein of herpes simplex virus inhibits reporter gene expression in the absence of other viral gene products.

Virology - 20 Aug 1995

Pak A S, Everly D N, Knight K, Read G S

Abstract excerpt

The virion host shutoff (vhs) function of herpes simplex virus induces degradation of host mRNAs at early times and rapid turnover of viral mRNAs throughout infection. Previous studies have shown that disruption of the UL41 gene abrogates vhs activity, but have not determined whether the UL41 polypeptide is the direct inducer of mRNA degradation or whether it is the only virion component required for this...

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PMID: 7645253
DOI: 10.1006/viro.1995.1431

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The virion host shutoff protein of herpes simplex virus inhibits reporter gene expression in the absence of other viral gene products.PMID 7645253Read ↗

Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide.Semantic proximity Read ↗

Evidence for Translational Regulation by the Herpes Simplex Virus Virion Host Shutoff ProteinSemantic proximity Read ↗

Mutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimeras.Semantic proximity Read ↗

Mutational analysis of the herpes simplex virus virion host shutoff protein: evidence that vhs functions in the absence of other viral proteins.Semantic proximity Read ↗

The herpes simplex virus host shutoff (vhs) RNase limits accumulation of double stranded RNA in infected cells: Evidence for accelerated decay of duplex RNASemantic proximity Read ↗

mRNA Decay during Herpesvirus Infections: Interaction between a Putative Viral Nuclease and a Cellular Translation FactorSemantic proximity Read ↗

Analysis of conserved domains of UL41 of herpes simplex virus type 1 in virion host shutoff and pathogenesis.Semantic proximity Read ↗

Herpes simplex virus infection stabilizes cellular IEX-1 mRNA.Semantic proximity Read ↗

Differentiation of the shutoff of protein synthesis by virion host shutoff and mutant gamma (1)34.5 genes of herpes simplex virus 1.Semantic proximity Read ↗

Site-directed mutagenesis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): analysis of functional differences between HSV type 1 (HSV-1) and HSV-2 alleles.Semantic proximity Read ↗

Translational arrest and mRNA decay are independent activities of alphaherpesvirus virion host shutoff proteinsSemantic proximity Read ↗

Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesisSemantic proximity Read ↗

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