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Article

Herpes simplex virus virion host shutoff (vhs) activity alters periocular disease in mice.

Journal of virology - 1 Apr 2000

Smith T J, Ackland-Berglund C E, Leib D A

Abstract excerpt

During lytic infection, the virion host shutoff (vhs) protein of herpes simplex virus (HSV) mediates the rapid degradation of RNA and shutoff of host protein synthesis. In mice, HSV type 1 (HSV-1) mutants lacking vhs activity are profoundly attenuated. HSV-2 has significantly higher vhs activity than HSV-1, eliciting a faster and more complete shutoff. To examine further the role of vhs activity in pathogenesis,...

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Identifiers

PMID: 10729135
DOI: 10.1128/jvi.74.8.3598-3604.2000
PMCID: PMC111869

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