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Article

A dominant-negative form of Serrate acts as a general antagonist of Notch activation.

Development (Cambridge, England) - 1 Sept 1997

Hukriede N A, Gu Y, Fleming R J

Abstract excerpt

Specification of the dorsal-ventral compartment boundary in the developing Drosophila wing disc requires activation of NOTCH from its dorsal ligand SERRATE and its ventral ligand DELTA. Both NOTCH ligands are required in this process and one cannot be substituted for the other. In the wing disc, expression of a dominant-negative, truncated form of SERRATE called BD(G), is capable of inhibiting NOTCH activation in...

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Identifiers

PMID: 9310337
DOI: 10.1242/dev.124.17.3427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A dominant-negative form of Serrate acts as a general antagonist of Notch activation.PMID 9310337Read ↗

Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development.Semantic proximity Read ↗

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.Semantic proximity Read ↗

The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation.Semantic proximity Read ↗

Lobe and Serrate are required for cell survival during early eye development in Drosophila.Semantic proximity Read ↗

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila.Semantic proximity Read ↗

Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor.Semantic proximity Read ↗

dAP-2 and defective proventriculus regulate Serrate and Delta expression in the tarsus of Drosophila melanogaster.Semantic proximity Read ↗

Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch.Semantic proximity Read ↗

Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc.Semantic proximity Read ↗

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila.Semantic proximity Read ↗

The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs.Semantic proximity Read ↗

The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.Semantic proximity Read ↗

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