Article
A dominant-negative form of Serrate acts as a general antagonist of Notch activation.
Development (Cambridge, England) - 1 Sept 1997
Hukriede N A, Gu Y, Fleming R J
Abstract excerpt
Specification of the dorsal-ventral compartment boundary in the developing Drosophila wing disc requires activation of NOTCH from its dorsal ligand SERRATE and its ventral ligand DELTA. Both NOTCH ligands are required in this process and one cannot be substituted for the other. In the wing disc,...
Topics
- Animals
- Base Sequence
- Calcium-Binding Proteins
- DNA Primers
- Drosophila
- Drosophila Proteins
- Female
- Gene Expression Regulation, Developmental
- Genes, Insect
- Intercellular Signaling Peptides and Proteins
- Intracellular Signaling Peptides and Proteins
- Jagged-1 Protein
- Ligands
- Male
- Membrane Proteins
- Mutation
- Phenotype
- Polymerase Chain Reaction