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Article

Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch.

Development (Cambridge, England) - 1 Jul 1999

Bishop S A, Klein T, Arias A M, Couso J P

Abstract excerpt

The receptor protein NOTCH and its ligands SERRATE and DELTA are involved in many developmental processes in invertebrates and vertebrates alike. Here we show that the expression of the Serrate and Delta genes patterns the segments of the leg in Drosophila by a combination of their signalling activities. Coincident stripes of Serrate and Delta expressing cells activate Enhancer of split expression in adjacent...

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Source

Identifiers

PMID: 10357942
DOI: 10.1242/dev.126.13.2993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch.PMID 10357942Read ↗

dAP-2 and defective proventriculus regulate Serrate and Delta expression in the tarsus of Drosophila melanogaster.Semantic proximity Read ↗

Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc.Semantic proximity Read ↗

Notch signalling mediates segmentation of the Drosophila leg.Semantic proximity Read ↗

Hox genes differentially regulate Serrate to generate segment-specific structures.Semantic proximity Read ↗

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.Semantic proximity Read ↗

The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation.Semantic proximity Read ↗

Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development.Semantic proximity Read ↗

A dominant-negative form of Serrate acts as a general antagonist of Notch activation.Semantic proximity Read ↗

Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage.Semantic proximity Read ↗

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila.Semantic proximity Read ↗

The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster.Semantic proximity Read ↗

Serrate2 is disrupted in the mouse limb-development mutant syndactylism.Semantic proximity Read ↗

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