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Article

Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development.

Development (Cambridge, England) - 1 Aug 1998

Klein T, Arias A M

Abstract excerpt

The Notch signalling pathway plays an important role during the development of the wing primordium, especially of the wing blade and margin. In these processes, the activity of Notch is controlled by the activity of the dorsal specific nuclear protein Apterous, which regulates the expression of the Notch ligand, Serrate, and the Fringe signalling molecule. The other Notch ligand, Delta, also plays a role in the...

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Identifiers

PMID: 9655817
DOI: 10.1242/dev.125.15.2951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interactions among Delta, Serrate and Fringe modulate Notch activity during Drosophila wing development.PMID 9655817Read ↗

A dominant-negative form of Serrate acts as a general antagonist of Notch activation.Semantic proximity Read ↗

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.Semantic proximity Read ↗

Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch.Semantic proximity Read ↗

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila.Semantic proximity Read ↗

Wing development and specification of dorsal cell fates in the absence of apterous in Drosophila.Semantic proximity Read ↗

The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation.Semantic proximity Read ↗

dAP-2 and defective proventriculus regulate Serrate and Delta expression in the tarsus of Drosophila melanogaster.Semantic proximity Read ↗

Notch pathway repression by vestigial is required to promote indirect flight muscle differentiation in Drosophila melanogaster.Semantic proximity Read ↗

Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc.Semantic proximity Read ↗

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila.Semantic proximity Read ↗

Fringe forms a complex with Notch.Semantic proximity Read ↗

Lobe and Serrate are required for cell survival during early eye development in Drosophila.Semantic proximity Read ↗

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