Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc.

doi:10.1242/dev.122.1.359

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Article

Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc.

Development (Cambridge, England) - 1 Jan 1996

de Celis J F, Garcia-Bellido A, Bray S J

Abstract excerpt

The cells along the dorsoventral boundary of the Drosophila wing imaginal disc have distinctive properties and their specification requires Notch activity. Later in development, these cells will form the wing margin, where sensory organs and specialised trichomes appear in a characteristic patter...

Topics

Alleles
Animals
Calcium-Binding Proteins
Drosophila
Drosophila Proteins
Female
Gene Expression Regulation, Developmental
Genes, Insect
Intercellular Signaling Peptides and Proteins
Intracellular Signaling Peptides and Proteins
Jagged-1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ligands

Male

Membrane Proteins

Mutation

Phenotype

Receptors, Notch

Serrate-Jagged Proteins

Source

Open in PubMed

Identifiers

PMID: 8565848
DOI: 10.1242/dev.122.1.359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8565848-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc.PMID 8565848Read ↗

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.Semantic proximity Read ↗

Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch.Semantic proximity Read ↗

Notch signalling mediates segmentation of the Drosophila leg.Semantic proximity Read ↗

Notch signaling directly controls cell proliferation in the Drosophila wing disc.Semantic proximity Read ↗

The tumour suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorsoventral boundary during Drosophila wing development.Semantic proximity Read ↗

A dominant-negative form of Serrate acts as a general antagonist of Notch activation.Semantic proximity Read ↗

A Delta-Notch signaling border regulated by Engrailed/Invected repression specifies boundary cells in the Drosophila hindgut.Semantic proximity Read ↗

Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing.Semantic proximity Read ↗

Opposing interactions between homothorax and Lobe define the ventral eye margin of Drosophila eye.Semantic proximity Read ↗

A permissive role of Notch in maintaining the DV affinity boundary of the Drosophila wing.Semantic proximity Read ↗

The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation.Semantic proximity Read ↗

Roles of the Notch gene in Drosophila wing morphogenesis.Semantic proximity Read ↗

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