Article
Methylation similarities of two CpG sites within exon 5 of human H19 between normal tissues and testicular germ cell tumours of adolescents and adults, without correlation with allelic and total level of expression.
British journal of cancer - 1 Jan 1997
Gillis A J, Verkerk A J, Dekker M C, van Gurp R J, Oosterhuis J W, Looijenga L H
Abstract excerpt
Testicular germ cell tumours (TGCTs) of adolescents and adults morphologically mimic different stages of embryogenesis. Established cell lines of these cancers are used as informative models to study early development. We found that, in contrast to normal development, TGCTs show a consistent biallelic expression of imprinted genes, including H19, irrespective of histology. Methylation of particular cytosine...
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