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Article

Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia

4 Jan 2008

Abstract excerpt

Genomic imprinting marks in the male germ line are already established in the adult germinal stem cell population. We studied the methylation patterns of H19 and MEST imprinted genes in sperm of control and oligozoospermic patients, by bisulphite genomic sequencing. We here report that 7 out of 15 (46.7%) patients with a sperm count below 10 x 10(6)/ml display defective methylation of H19 and/or MEST imprinted...

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Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18178607
DOI: 10.1093/molehr/gam093

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