Article
Mouse parthenogenetic embryos with monoallelic H19 expression can develop to day 17.5 of gestation.
Developmental biology - 15 Mar 2002
Kono Tomohiro, Sotomaru Yusuke, Katsuzawa Yukiko, Dandolo Luisa
Abstract excerpt
In mammals, both maternal and paternal genomes are required for a fetus to develop normally to term. This requirement is due to the epigenetic modification of genomes during gametogenesis, which leads to an unequivalent expression of imprinted genes between parental alleles. Parthenogenetic mouse embryos that contain genomes from nongrowing (ng) and fully grown (fg) oocytes can develop into 13.5-day-old fetuses,...
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