Article
Laboratory Testing for the Evaluation of Phenotypic Activated Protein C Resistance.
Seminars in thrombosis and hemostasis - 1 Sept 2022
Morimont Laure, Donis Nathalie, Bouvy Céline, Mullier François, Dogné Jean-Michel, Douxfils Jonathan
Abstract excerpt
Activated protein C (APC) resistance (APCR) is considered a risk factor of venous thromboembolism (VTE). The most common genetic disorder conferring APCR is a factor (F) V Leiden mutation, but many other factors are also implicated, such as other F5 mutations (e.g., FV Hong-Kong and FV Cambridge), protein S deficiency, elevated factor VIII, exogenous hormone use, pregnancy and postpartum, depending on how APCR is...
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