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Article

Coagulation assay with improved specificity to factor V mutants insensitive to activated protein C.

Thrombosis research - 1 Nov 1995

Kraus M, Zander N, Fickenscher K

Abstract excerpt

The prevalence of a new hereditary defect in the protein C anticoagulant pathway, the factor V-Leiden, has been reported to range between 20% to 60% in familial thrombophilia. In addition to differences in patient groups, these very divergent numbers might also be due to the detection method applied. In most studies a modified APTT was used, where activated protein C (APC) is added simultaneously with the start...

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Source

Identifiers

PMID: 8578552
DOI: 10.1016/0049-3848(95)00174-p

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coagulation assay with improved specificity to factor V mutants insensitive to activated protein C.PMID 8578552Read ↗

Use of modified functional assays for activated protein C resistance in patients with basally prolonged aPTT.Semantic proximity Read ↗

A comparison between two activated protein C resistance methods as routine diagnostic tests for factor V Leiden mutation.Semantic proximity Read ↗

Laboratory Testing for the Evaluation of Phenotypic Activated Protein C Resistance.Semantic proximity Read ↗

Clinical evaluation of a new functional test for detection of activated protein C resistance (Pefakit APC-R Factor V Leiden) at two centers in Europe and the USA.Semantic proximity Read ↗

Careful selection of sample dilution and factor-V-deficient plasma makes the modified activated protein C resistance test highly specific for the factor V Leiden mutation.Semantic proximity Read ↗

Factor V is an anticoagulant cofactor for activated protein C during inactivation of factor Va.Semantic proximity Read ↗

A modification of the APC resistance test and its application to the study of patients on coumarin therapy.Semantic proximity Read ↗

Determinants of the APTT- and ETP-based APC sensitivity tests.Semantic proximity Read ↗

Activated protein C resistance assay detects thrombotic risk factors other than factor V Leiden.Semantic proximity Read ↗

Modification of the ProC Global assay using dilution of patient plasma in factor V-depleted plasma as a screening assay for factor V Leiden mutation.Semantic proximity Read ↗

Investigation of genotype-dependent differences in factor V activity as well as response to activated protein C by application of different methods.Semantic proximity Read ↗

Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene.Semantic proximity Read ↗

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