Coagulation assay with improved specificity to factor V mutants insensitive to activated protein C.

doi:10.1016/0049-3848(95)00174-p

Back to search

Article

Coagulation assay with improved specificity to factor V mutants insensitive to activated protein C.

Thrombosis research - 1 Nov 1995

Kraus M, Zander N, Fickenscher K

Abstract excerpt

The prevalence of a new hereditary defect in the protein C anticoagulant pathway, the factor V-Leiden, has been reported to range between 20% to 60% in familial thrombophilia. In addition to differences in patient groups, these very divergent numbers might also be due to the detection method appl...

Topics

Administration, Oral
Anticoagulants
Factor V
Factor VIII
Heparin
Humans
Mutation
Partial Thromboplastin Time
Protein C
Risk Factors
Thrombosis

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.