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Article

Congenital resistance to activated protein C in patients with lupus anticoagulants: evaluation of two functional assays.

Thrombosis and haemostasis - 1 Aug 1998

Galli M, Duca F, Ruggeri L, Finazzi G, Negri B, Moia M

Abstract excerpt

The R506Q mutation ("Factor V Leiden") is responsible for the resistance to activated Protein C (aPCR), that is evaluated by coagulation tests. Such tests cannot be used in patients with lupus anticoagulants (LAs), due to the interfering effect exerted by these antibodies on "in vitro" phospholipid-dependent coagulation tests. For this reason, assays have been developed to evaluate aPCR that are insensitive to...

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PMID: 9716147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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