Article
Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease.
Annals of neurology - 1 Sept 1997
Scott W K, Saunders A M, Gaskell P C, Locke P A, Growdon J H, Farrer L A, Auerbach S A, Roses A D, Haines J L, Pericak-Vance M A
Abstract excerpt
We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3...
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