Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic sequence analysis of a key residue (Arg183) in human G alpha q in invasive non-functional pituitary adenomas.

Clinical endocrinology - 1 Aug 1997

Farrell W E, Talbot J A, Bicknell E J, Simpson D, Clayton R N

Abstract excerpt

OBJECTIVE: With isolated exceptions the only oncogene significantly associated with pituitary tumours is a constitutively active Gs protein (G alpha s). The recent cloning of the cDNA of human G alpha q has facilitated the study of this activator of the phospholipase C beta/Ca2+/ protein kinase C pathway. Since, with isolated exceptions, non-functional tumours are responsive in vitro to TRH and GnRH which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to TRH gene
Share to GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Mutation

Share to Pituitary Neoplasms

Share to Polymerase Chain Reaction

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 9302401
DOI: 10.1046/j.1365-2265.1997.2891088.x

Genes

TRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic sequence analysis of a key residue (Arg183) in human G alpha q in invasive non-functional pituitary adenomas.PMID 9302401Read ↗

Pituitary adenomas: screening for G alpha q mutations.Semantic proximity Read ↗

Oncogenic mutations of alpha-Gi2 protein are not determinant for human adrenocortical tumourigenesis.Semantic proximity Read ↗

Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G).Semantic proximity Read ↗

Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes.Semantic proximity Read ↗

Absence of constitutively activating mutations in the GHRH receptor in GH-producing pituitary tumors.Semantic proximity Read ↗

A new constitutively activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours.Semantic proximity Read ↗

G-proteins and hormonal signalling in human pituitary tumors: genetic mutations and functional alterations.Semantic proximity Read ↗

G protein mutations in tumours of the pituitary, parathyroid and endocrine pancreas.Semantic proximity Read ↗

Analysis of GNAS mutations in 60 growth hormone secreting pituitary tumors: correlation with clinical and pathological characteristics and surgical outcome based on highly sensitive GH and IGF-I criteria for remission.Semantic proximity Read ↗

Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations.Semantic proximity Read ↗

Expression of pituitary tumour-derived, N-terminally truncated isoform of fibroblast growth factor receptor 4 (ptd-FGFR4) correlates with tumour invasiveness but not with G-protein alpha subunit (gsp) mutation in human GH-secreting pituitary adenomas.Semantic proximity Read ↗

Genetic aspects of pituitary tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.