Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pituitary adenomas: screening for G alpha q mutations.

The Journal of clinical endocrinology and metabolism - 1 Dec 1997

Oyesiku N M, Evans C O, Brown M R, Blevins L S, Tindall G T, Parks J S

Abstract excerpt

Mutant, guanosine triphosphatase-deficient, alpha-subunits of the G protein, Gs, gsp ocogene have been discovered in 40% of GH-secreting pituitary adenomas. Therefore, we hypothesized that a novel G protein class, G alpha q, involved in pituitary signal transduction, might be involved in pituitary tumorigenesis. Recombinant mutations of G alpha q result in constitutive activation of phospholipase C and have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Base Sequence

Share to DNA, Complementary

Share to Mutation

Share to Polymerase Chain Reaction

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 9398737
DOI: 10.1210/jcem.82.12.4436

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pituitary adenomas: screening for G alpha q mutations.PMID 9398737Read ↗

Genomic sequence analysis of a key residue (Arg183) in human G alpha q in invasive non-functional pituitary adenomas.Semantic proximity Read ↗

G-proteins and hormonal signalling in human pituitary tumors: genetic mutations and functional alterations.Semantic proximity Read ↗

GS protein mutations and pituitary tumors: functional correlates and possible therapeutic implications.Semantic proximity Read ↗

Gs protein mutations and the pathogenesis and function of pituitary tumors.Semantic proximity Read ↗

Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors.Semantic proximity Read ↗

G protein mutations in endocrine diseases.Semantic proximity Read ↗

Characteristics of gsp-positive growth hormone-secreting pituitary tumors in Korean acromegalic patients.Semantic proximity Read ↗

Activating genomic alterations in the Gs alpha gene ( GNAS ) in 274 694 tumorsSemantic proximity Read ↗

[Pituitary adenoma: mechanisms of endocrine oncogenesis].Semantic proximity Read ↗

Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes.Semantic proximity Read ↗

[Endocrine tumors associated to protein Gsalpha/Gi2alpha mutations].Semantic proximity Read ↗

G protein mutations in pituitary tumors: a study on Turkish patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.