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Article

Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations.

Journal of endocrinological investigation - 1 Nov 2008

Ruggeri R M, Santarpia L, Curtò L, Torre M L, Galatioto M, Galatioto S, Trimarchi F, Cannavò S

Abstract excerpt

BACKGROUND: Mutations of the genes encoding the alpha subunit of the stimulatory G protein (Gs) and of the inhibiting Gi2 protein (GNAS1 and GNAI2 genes, respectively) have been described in various endocrine neoplasias, including pituitary tumors. AIM: To search for mutations of GNAS1 and GNAI2 in a continuous series of non-functioning pituitary adenoma (NFPA) patients neurosurgically treated. SUBJECTS AND...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19169048
DOI: 10.1007/BF03345630

Genes

GNAI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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